Saturday, January 4, 2020
How Do Pentraxins Help Detect Alzheimer s Disease Humans
Briana Momchilovich BIO 206 Writing Assignment #3 Detailed focus question: How do pentraxins help detect AlzheimerÃ¢â¬â¢s disease in humans? I. At the beginning to have a good understanding of the topic I will explain what the functions or calcium-binding proteins and the locations of calcium-binding proteins. I am going to do this so the reader has a better background understanding on the main topic of the paper. A. Functions of calcium-binding proteins (Swanson el al., 1992). 1. Regulates mostly cellular processes. a. They are needed for second messenger signals. 2. Calcium-binding proteins bind directly to Ca2+. a. Regulates the amount of Ca2+ in the cytosol. 3. They have a huge effect on neurons. a. This has an effect on learning andÃ¢â¬ ¦show more contentÃ¢â¬ ¦3. The C-reactive protein is usually produced in the liver of humans. C. SAP Ã¢â¬â Serum amyloid P (Swanson el al., 1992). 1. The basic feature of serum amyloid P is it has a high relationship with phospholipids that are negatively charged. 2. The function of serum amyloid P binds to calcium and it consists of a dimer of pentamer. a. This allows for defense from pathogens from the body. 3. Serum amyloid P is usually produced in the liver of humans. III. This last section I will combine all of the ideas that were made above. I will talk about what AlzheimerÃ¢â¬â¢s disease is and how C-reactive proteins and serum amyloid P proteins relationship to AlzheimerÃ¢â¬â¢s disease. A. AlzheimerÃ¢â¬â¢s disease is a very common disease in the older generations (Dominguez-Prieto el al., 2017). 1. The disease is a progressive disease and it ends up leading to loss of memory. 2. AlzheimerÃ¢â¬â¢s disease is caused by the increase of beta-amyloid protein. a. Beta-amyloid protein is what leads to nerve cells dying. 3. Genetic too have a lot to do with AlzheimerÃ¢â¬â¢s disease also. a. When a person has a certain gene mutation they are a lot more likely to have AlzheimerÃ¢â¬â¢s disease. b. The apoE4 gene is the gene that has the strongest correlation with AlzheimerÃ¢â¬â¢s disease. B. C-reactive proteins relationship to AlzheimerÃ¢â¬â¢s disease (Yarchoan el al., 2013). 1. There is an increase of C-reactive proteins in people that have AlzheimerÃ¢â¬â¢s disease.